STUDY OF THE PROCESS EXTRACTION OF HYPERICIN FROM THE AERIAL PARTS OF HYPERICUM SCABRUM AND HYPERICUM PERFORATUM

The process extraction of hypericin from the aerial parts Hypericum scabrum and perforatum was studied. On basis results research, following conditions were established: extractant – 80% ethanol, particle size raw material no more than 8 mm temperature 20–40 °C. By method mathematical planning experiment according to Box-Wilson, determined, which ensure with a yield 95%. Proposed five-fold H. necessary infusion at first contact phases 6 hours, second 5 third fourth 4 hours fifth 2 hours. proposed united technology for obtaining «Dry extract Hypericum» scabrum. tested Technology center GMP requirements by Institute Chemistry Plant Substances, Academy Sciences Republic Uzbekistan. More 500.0 kg substance adequate Technical Conditions 03535440-022: 2016 has been produced.